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GENES AND EXPERIENCE:Behavioral Characteristics, Alcoholism

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Neurological Basis of Behavior (PSY - 610)
VU
Lesson 12
GENES AND EXPERIENCE
Objective:
·  To understand the Brain behaviour relationships from the perspectives of biological systems.
In this section of the module the students would go through and understand Biological systems- their
genetic basis and similarities with other animals. Mendelian Genetics. Where is the genetic
programming of behaviour (if any) Watson Crick Model. What are the similarities and differences
between species, progenies of higher order animals, including homosapien? How much do genes
contribute to behaviour: The discipline of Behavior genetics?
Behavioral Characteristics
In this lesson we will continue with the discussion on the genetic basis of higher order behaviours. In
the last lesson, we had discussed Schizophrenia which has strong genetic basis as shown by research.
Intelligence: Sir Francis Galton and Darwin were first cousins. Both started new ways of thinking. Sir
Francis Galton laid the basis of Statistics and Darwin gave us the theory of Evolution. Galton studied
the lineage of famous English men found genius is hereditary but we cannot rule out the possibility of
environmental influences ( upper class, royalty provided better breeding grounds for training children to
take on important assignments--like training a crown prince). Sir Julian Huxley (Biologist) Aldous
Huxley (writer), both grandsons of Thomas Henry Huxley and great grandson of Leonard Huxley. Thus
it appears genius runs in the family! John Noyes started a new thinking called Eugenics, where he
propagated that scientific breeding can produce brilliant offspring leading to perfectionism. He initiated
a complex system of community living of highly educated and well to do professionals. There were 58
children born in the community. They were healthy only 6/58 died compared to the mortality rate of 45.
The surviving children started corporations, hospitals which were bases of present day entrepreneurship
and businesses of the US.
The view that intelligence is inherited is controversial as there are several issues which come up-
how is intelligence defined or measured?
Intelligence is a sum total of many abilities. It is possible that these are inherited, but there is evidence
that environmental stimulation does make a difference (early stimulation?). It is well documented that
black children who performed poorly on IQ tests when coached on test taking showed an improvement
of scores of as much as 20 points. This coaching is more effective if children younger.  Early
stimulation is important.
Environmental influences:
Environmental influences can affect intelligence, if the same individual is tested again after a period of
several years it is possible to gain about 20 points (Does this mean IQ increased?)
In Israel children have to live in the Kibbutz, separate from their parents. Children in Kibbutz coming
from European descent had I.Q. scores above 100 points, whereas children from Oriental/African
descent 80-90 points. However after 4-5 years their scores are similar.
Similarly, Monozygotic (MZ) twins reared together had a higher correlation on IQ scores(r=.92). This is
the same for height, weight, and school achievement. When MZ are reared separately the correlation of
IQ falls to .88 and school achievement falls to .66. In Dizygotic (DZ) and siblings the correlation falls
and in unrelated individuals the correlation of IQ falls to .25.
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Neurological Basis of Behavior (PSY - 610)
VU
Critical thinking about intelligence testing
1. Is Intelligence influenced by culture?
2. Intelligence Tests?? Do they measure innate intellectual capacities or cultural learning?
Alcoholism: is another trait which evidence has shown to be genetically linked, especially that it is
transmitted from father to sons. Longitudinal studies have been carried out in Scandinavian countries
by Goodwin and colleagues (1979) as it is possible to follow children in foster homes through
records. It was reported that predisposition to alcoholism is 4 times higher in males. Research by
Schukit, Goodman and Winokur (1972) showed that alcoholism in half sisters or half brothers with
an alcoholic parent (living with them as well) was 46% (same if they did not live with alcoholic
parents). On the other hand, if foster parents were alcoholic the frequency is much lower about 15%.
There have been a large number of researches to identify the genetic basis of other behaviors. In one
study it was reported genetic predisposition to opiate addiction in rats. Rats were fond of morphine,
preferred it over water after tasting it for the first time!
We still have a lot of research to do before we can separate clearly the effects of environment or
environment and it is ongoing keeping in view the large number of variables.
References:
1. Kalat J.W (1998) Biological Psychology Brooks/ Cole Publishing
2. Carlson N.R.(2005) Foundations of Physiological Psychology Allyn and Bacon, Boston
3. Pinel, John P.J. (2003) Biopsychology (5th edition) Allyn and Bacon Singapore
4 Bloom F, Nelson and Lazerson (2001), Behavioral Neuroscience: Brain, Mind and Behaviors (3rd
edition) Worth Publishers New York
6. Bridgeman,B (1988)The Biology of Behaviour and Mind. John Wiley and Sons New York
7. Brown, T.S and Wallace P.S. (1980) Physiological Psychology. Academic Press New York
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Table of Contents:
  1. INTRODUCTION:Descriptive, Experimental and/ or Natural Studies
  2. BRIEF HISTORICAL REVIEW:Roots of Behavioural Neurosciences
  3. SUB-SPECIALIZATIONS WITHIN THE BEHAVIORAL NEUROSCIENCES
  4. RESEARCH IN BEHAVIOURAL NEUROSCIENCES:Animal Subjects, Experimental Method
  5. EVOLUTIONARY AND GENETIC BASIS OF BEHAVIOUR:Species specific
  6. EVOLUTIONARY AND GENETIC BASIS OF BEHAVIOUR:Decent With Modification
  7. EVOLUTIONARY AND GENETIC BASIS OF BEHAVIOUR:Stereoscopic vision
  8. GENES AND EXPERIENCE:Fixed Pattern, Proteins, Genotype, Phenotypic
  9. GENES AND EXPERIENCE:Mendelian Genetics, DNA, Sex Influenced Traits
  10. GENES AND EXPERIENCE:Genetic Basis of behavior, In breeding
  11. GENES AND EXPERIENCE:Hybrid vigor, Chromosomal Abnormalities
  12. GENES AND EXPERIENCE:Behavioral Characteristics, Alcoholism
  13. RESEARCH METHODS AND TECHNIQUES OF ASSESSMENT OF BRAIN FUNCTION
  14. RESEARCH METHODS AND TECHNIQUES OF ASSESSMENT OF BRAIN FUNCTION:Activating brain
  15. RESEARCH METHODS AND TECHNIQUES OF ASSESSMENT OF BRAIN FUNCTION:Macro electrodes
  16. RESEARCH METHODS AND TECHNIQUES OF ASSESSMENT OF BRAIN FUNCTION:Water Mazes.
  17. DEVELOPMENT OF THE NERVOUS SYSTEM:Operation Head Start
  18. DEVELOPMENT OF THE NERVOUS SYSTEM:Teratology studies, Aristotle
  19. DEVELOPMENT OF THE NERVOUS SYSTEM:Stages of development, Neurulation
  20. DEVELOPMENT OF THE NERVOUS SYSTEM:Cell competition, Synaptic Rearrangement
  21. DEVELOPMENT OF THE NERVOUS SYSTEM:The issues still remain
  22. DEVELOPMENT OF THE NERVOUS SYSTEM:Post natal
  23. DEVELOPMENT OF THE NERVOUS SYSTEM:Oxygen level
  24. Basic Neuroanatomy:Brain and spinal cord, Glial cells, Oligodendrocytes
  25. Basic Neuroanatomy:Neuron Structure, Cell Soma, Cytoplasm, Nucleolus
  26. Basic Neuroanatomy:Control of molecules, Electrical charges, Proximal-distal
  27. Basic Neuroanatomy:Telencephalon, Mesencephalon. Myelencephalon
  28. Basic Neuroanatomy:Tegmentum, Substantia Nigra, MID BRAIN areas
  29. Basic Neuroanatomy:Diencephalon, Hypothalmus, Telencephalon, Frontal Lobe
  30. Basic Neurochemistry:Neurochemicals, Neuromodulator, Synaptic cleft
  31. Basic Neurochemistry:Changes in ionic gates, The direct method, Methods of Locating NT
  32. Basic Neurochemistry:Major Neurotransmitters, Mesolimbic, Metabolic degradation
  33. Basic Neurochemistry:Norepinephrine/ Noradrenaline, NA synthesis, Noadrenergic Pathways
  34. Basic Neurochemistry:NA and Feeding, NE and self stimulation: ICS
  35. Basic Neurochemistry:5HT and Behaviors, Serotonin and sleep, Other behaviours
  36. Basic Neurochemistry:ACH and Behaviors, Arousal, Drinking, Sham rage and attack
  37. Brain and Motivational States:Homeostasis, Temperature Regulation, Ectotherms
  38. Brain and Motivational States:Biological Rhythms, Circadian rhythms, Hunger/Feeding
  39. Brain and Motivational States:Gastric factors, Lipostatic theory, Neural Control of feeding
  40. Brain and Motivational States:Resting metabolic state, Individual differences
  41. Brain and Motivational States:Sleep and Dreams, Characteristics of sleep
  42. Higher Order Brain functions:Brain correlates, Language, Speech Comprehension
  43. Higher Order Brain functions:Aphasia and Dyslexia, Aphasias related to speech
  44. Higher Order Brain Functions:Principle of Mass Action, Long-term memory
  45. Higher Order Brain Functions:Brain correlates, Handedness, Frontal lobe